Open AccessValproic acid enhances the viability of random pattern skin flaps: involvement of enhancing angiogenesis and inhibiting oxidative stress and apoptosis
Author(s) -
Hongqiang Wu,
Jian Ding,
Lei Wang,
Jinti Lin,
Shihen Li,
Guangheng Xiang,
Liangfu Jiang,
Huazi Xu,
Weiyang Gao,
Kailiang Zhou
Publication year - 2018
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s186222
Subject(s) - angiogenesis , valproic acid , medicine , oxidative stress , vascular endothelial growth factor , apoptosis , h&e stain , pharmacology , surgery , immunohistochemistry , pathology , biology , epilepsy , biochemistry , psychiatry , vegf receptors
Random skin flaps are commonly applied during plastic surgery, but distal flap necrosis limits their clinical applications. Valproic acid (VPA), a histone deacetylase inhibitor and a traditional antiepileptic agent, may promote flap survival.