Open AccessThe therapeutic effects of traditional Chinese medicine Fusu agent in LPS-induced acute lung injury model rats
Author(s) -
Peiyang Gao,
Ziyi Zhao,
Chuantao Zhang,
Chunxia Wang,
Kunlan Long,
Liuxue Guo,
Baixue Li
Publication year - 2018
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s181798
Subject(s) - pharmacology , medicine , inflammation , therapeutic effect , oxidative stress , lung , umbilical vein , endothelium , endothelial stem cell , vascular permeability , immunology , in vitro , chemistry , pathology , biochemistry
Acute lung injury (ALI) is a common and fatal oxidative stress in the lung, mainly induced by endothelial injury and capillary leakage. In our previous study, "Fusu agent", a traditional Chinese medicine, was found to exert preventive effect on endothelial damage in lipopoly-saccharide (LPS)-induced ALI model rats partially via inhibiting heparanase1 (HPA1) activation and inhibiting the inflammatory factors. However, it is still unknown whether Fusu agent exerts its therapeutic effect in LPS-induced ALI model rats and its potential mechanism.