Open AccessAstragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB P65 subunit
Author(s) -
Xiaolei Wang,
Yutong Gao,
Na Tian,
Zhiyao Zhu,
Tao Wang,
Jiayi Xu,
Bingjie Wu,
Nan Zhang
Publication year - 2018
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s174058
Subject(s) - autophagy , sirtuin 1 , activator (genetics) , fibrosis , chemistry , acetylation , pharmacology , sirtuin , endocrinology , medicine , downregulation and upregulation , biochemistry , apoptosis , receptor , gene
Mesangial cell (MC) activation plays an important role in many glomerular diseases associated with renal fibrosis, including diabetic kidney disease (DKD). The aim of this study was to determine whether Astragaloside IV (AS-IV) modulated MC activation in DKD via autophagy by specifically regulating the autophagy inducer sirtuin 1 (SIRT1).