Open AccessPopulation Pharmacokinetics of CC-122
Author(s) -
Yiming Cheng,
Jian Chen,
Michael Pourdehnad,
Simon Zhou,
Yan Li
Publication year - 2021
Publication title -
clinical pharmacology
Language(s) - English
Resource type - Journals
ISSN - 1179-1438
DOI - 10.2147/cpaa.s310604
Subject(s) - pharmacokinetics , population pharmacokinetics , volume of distribution , population , medicine , covariate , compartment (ship) , distribution (mathematics) , pharmacology , oncology , statistics , mathematics , mathematical analysis , oceanography , environmental health , geology
CC-122 is a cereblon-modulating agent that exerts direct cell-autonomous activity against malignant B cells and immunomodulatory effects. Herein, a population pharmacokinetic (popPK) model of CC-122 was developed and the influence of demographic and disease-related covariates on population pharmacokinetic parameters was assessed based on data from three clinical studies of CC-122 (dose range, 0.5-15 mg) in healthy subjects and cancer patients.