Open AccessA Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Assessing Efficacy and Safety of a Novel Low-Dose Turmeric Extract Formulation in Healthy Adults with Chronic Knee Pain
Author(s) -
Shefali Thanawala,
Rajat Shah,
Somepalli Venkateswarlu,
Krishnaraju Venkata Alluri,
Prabakaran Desomayanandam,
Arun Bhuvanendran
Publication year - 2021
Publication title -
clinical pharmacology
Language(s) - English
Resource type - Journals
ISSN - 1179-1438
DOI - 10.2147/cpaa.s307464
Subject(s) - placebo , medicine , visual analogue scale , adverse effect , randomized controlled trial , anesthesia , knee pain , quality of life (healthcare) , clinical endpoint , chronic pain , osteoarthritis , physical therapy , alternative medicine , nursing , pathology
Knee pain causes functional limitations, eventually compromising the quality of life. We evaluated the efficacy of our water-dispersible turmeric formulation (60% natural curcuminoids, TurmXTRA 60N ® -WDTE60N), which exhibited better PK profile at low dose (250 mg) than standard turmeric extract, in alleviating symptoms of chronic knee pain.