Open AccessMetformin as a Potential Adjuvant Antimicrobial Agent Against Multidrug Resistant Bacteria
Author(s) -
Majed M. Masadeh,
Karem H. Alzoubi,
Majd M. Masadeh,
Zainah O Aburashed
Publication year - 2021
Publication title -
clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 27
ISSN - 1179-1438
DOI - 10.2147/cpaa.s297903
Subject(s) - antibiotics , metformin , antimicrobial , multiple drug resistance , antibiotic resistance , microbiology and biotechnology , medicine , pharmacology , adjuvant , rifampicin , biology , insulin
The continuous increase in the incidence of bacterial resistance to existing antibiotics represents a worldwide health burden. A surrogate strategy to combat such crisis is to find compounds that restore the antimicrobial activity of the already existing antibiotics against multidrug resistant bacteria. Metformin is a commonly used antidiabetic medication. It has proven benefits in other diseases including cancer, aging-related and infectious diseases. In this study, the potential effect of metformin as an adjuvant therapy to antibiotics was investigated.