Open Access<p>Vitamin D Pretreatment Attenuates Ciprofloxacin-Induced Antibacterial Activity</p>
Author(s) -
Majed M. Masadeh,
Karem H. Alzoubi,
Bashar Al-Taani,
Majd M. Masadeh,
Zainah O Aburashed,
Nasr Alrabadi
Publication year - 2020
Publication title -
clinical pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 27
ISSN - 1179-1438
DOI - 10.2147/cpaa.s268330
Subject(s) - ciprofloxacin , microbiology and biotechnology , staphylococcus aureus , antimicrobial , staphylococcus epidermidis , pseudomonas aeruginosa , chemistry , bacteria , biology , antibiotics , genetics
Ciprofloxacin is an antimicrobial that is commonly used to treat several types of infections. It exerts its antimicrobial activity through interfering with bacterial DNA replication and transcription, leading to increase oxidative stress and eventually bacterial death. Vitamin D, on the other hand, has been found to have DNA protective and antioxidant effects. In the current study, the possible interactive effect of vitamin D on ciprofloxacin-induced cytotoxicity was investigated in various standard bacterial strains.