Open Access<p>Overexpression of Adiponectin Receptors in Opium Users with and without Cancer</p>
Author(s) -
Negar Firouzabadi,
Maral Haghnegahdar,
Bahman Khalvati,
Ali Dehshahri,
Ehsan Bahramali
Publication year - 2020
Publication title -
clinical pharmacology
Language(s) - English
Resource type - Journals
ISSN - 1179-1438
DOI - 10.2147/cpaa.s256289
Subject(s) - opium , medicine , receptor , cancer , downregulation and upregulation , traditional medicine , oncology , biology , political science , gene , genetics , law
Opium addiction is a serious public health concern in the Middle East countries causing various illnesses. Opium use is associated with an increased risk of several cancers; however, the underlying mechanisms are not yet fully elucidated. Altered levels of adiponectin and its related main receptors, Adiponectin receptor 1 and 2 (AdipoR1 and AdipoR2) have been associated with several malignancies. Opium users are at risk of various cancers. All together let us to the hypothesis that probable overexpression of AdipoRs in opium users might be linked to the occurrence of cancer in this population.