Open Access<p>Phytochemical and Antiulcer Activity Screening of Seed Extract of <em>Cordia africana</em> Lam (Boraginaceae) in Pyloric Ligated Rats</p>
Author(s) -
Yazachew Engida Yismaw,
Mohammedbrhan Abdelwuhab,
Digambar Ambikar,
Ayenew Engida Yismaw,
Dagninet Derebe,
Wondim Melkam
Publication year - 2020
Publication title -
clinical pharmacology
Language(s) - English
Resource type - Journals
ISSN - 1179-1438
DOI - 10.2147/cpaa.s245672
Subject(s) - phytochemical , medicine , traditional medicine , famotidine , boraginaceae , population , antiulcer drug , pharmacology , drug , biology , botany , environmental health
Peptic ulcer disease represents a worldwide health problem because of its high morbidity, mortality and economic loss. It is a very prevalent condition affecting around 10%-15% of the general population worldwide. Most of the available antiulcer drugs are costly and have an incidence of relapse, drug interactions and several side effects upon chronic usage. Hence, the use of herbal medicine may be safe, economical and effective in such cases when drugs are used for long periods. Ethnobotanical reports showed traditional claims on the use of Cordia africana seeds for the treatment of gastric ulcers. However, the safety and efficacy of these remedies are not well known. The aim of this study is, therefore, to evaluate the antiulcer activity and safety of a crude extract of C. africana seeds in animal models.