Open AccessNCOA4-Mediated Ferroptosis in Bronchial Epithelial Cells Promotes Macrophage M2 Polarization in COPD Emphysema
Author(s) -
Jiaxin Liu,
Zixiao Zhang,
Yue Yang,
Tingting Di,
Yan Wang,
Tao Bian
Publication year - 2022
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s354896
Subject(s) - macrophage polarization , pathogenesis , copd , macrophage , immunology , medicine , pathology , cancer research , biology , in vitro , biochemistry
Macrophage polarization plays an important role in the pathogenesis of COPD emphysema. Changes in macrophage polarization in COPD remain unclear, while polarization and ferroptosis are essential factors in its pathogenesis. Therefore, this study investigated the relationship between macrophage polarization and ferroptosis in COPD emphysema.