Open AccessBlood Eosinophils in Chinese COPD Participants and Response to Treatment with Combination Low-Dose Theophylline and Prednisone: A Post-Hoc Analysis of the TASCS Trial
Author(s) -
Thomas L. Bradbury,
Gian Luca Di Tanna,
Anish Scaria,
Allison Martin,
Fuqiang Wen,
Nanshan Zhong,
Jinping Zheng,
Peter J. Barnes,
Bartolomé R. Celli,
Norbert Berend,
Christine Jenkins
Publication year - 2022
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s339889
Subject(s) - medicine , copd , prednisone , exacerbation , placebo , theophylline , spirometry , asthma , post hoc analysis , bronchodilator , gastroenterology , pathology , alternative medicine
The burden of chronic obstructive pulmonary disease (COPD) disproportionately affects patients in low to middle-income countries. Although the Theophylline and Steroids in COPD Study (TASCS) showed no clinical benefit from administering low-dose theophylline and prednisone in COPD patients compared to placebo, it was hypothesized that those with elevated blood eosinophil counts would receive clinical benefit from the intervention.