Open AccessGSK-3β Inhibitors Attenuate the PM2.5-Induced Inflammatory Response in Bronchial Epithelial Cells
Author(s) -
Weifeng Zou,
Ye Dong,
Sha Li,
Jinxing Hu,
Zhu Tao,
Fang He,
Pixin Ran
Publication year - 2021
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s327887
Subject(s) - downregulation and upregulation , gsk 3 , inflammation , phosphorylation , gsk3b , signal transduction , kinase , proinflammatory cytokine , nf κb , medicine , iκbα , immunology , cancer research , biology , microbiology and biotechnology , biochemistry , gene
PM2.5-associated airway inflammation has recently been recognized as pivotal to the development of COPD. Aberrant glycogen synthase kinase (GSK)-3β signaling is linked to the inflammatory response. Therefore, we investigated the effects of GSK-3β inhibitors on the PM2.5-induced inflammatory response in bronchial epithelial cells.