Open AccessEstimated Prevalence and Number of PiMZ Genotypes of Alpha-1 Antitrypsin in Seventy-Four Countries Worldwide
Author(s) -
Cristina Martínez-González,
Ignacio Blanco,
I. Diego,
Patrícia Bueno,
Marc Miravitlles
Publication year - 2021
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s327803
Subject(s) - population , genotyping , confidence interval , epidemiology , geography , demography , environmental health , medicine , genotype , biology , sociology , gene , biochemistry
The α-1 antitrypsin (AAT) protease inhibitor PiMZ is a moderately deficient genotype, until recently considered of little or negligible risk. However, a growing number of studies show that MZ carriers have an increased risk of developing lung and liver diseases, if exposed to smoking or other airborne or industrial pollutants, and hepatotoxic substances.