Open AccessMiR-361-5p/abca1 and MiR-196-5p/arhgef12 Axis Involved in γ-Sitosterol Inducing Dual Anti-Proliferative Effects on Bronchial Epithelial Cells of Chronic Obstructive Pulmonary Disease
Author(s) -
Shen Huifen,
Ying Li,
Pingping Qu,
Yu Tang,
Bingbing Li,
Guoliang Cheng
Publication year - 2021
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s326015
Subject(s) - copd , medicine , microrna , western blot , pi3k/akt/mtor pathway , rhoa , cell growth , pathogenesis , cell , cancer research , immunology , signal transduction , biology , microbiology and biotechnology , gene , biochemistry , genetics
Chronic obstructive pulmonary disease (COPD), a progressive and irreversible respiratory disease, becomes the third leading cause of death and results in enormous economic burden on healthcare costs and productivity loss worldwide by 2020. Thus, it is urgent to develop effective anti-COPD drugs.