Open AccessTRONARTO: A Randomized, Placebo-Controlled Study of Tiotropium/Olodaterol Delivered via Soft Mist Inhaler in COPD Patients Stratified by Peak Inspiratory Flow
Author(s) -
Donald A. Mahler,
Andrea Ludwig-Sengpiel,
Gary T. Ferguson,
Alberto de la Hoz,
John Ritz,
Asif Shaikh,
Henrik Watz
Publication year - 2021
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s324467
Subject(s) - medicine , placebo , copd , inhaler , anesthesia , bronchodilator , dry powder inhaler , randomized controlled trial , confidence interval , tiotropium bromide , inhalation , asthma , lung function , lung , alternative medicine , pathology
Inhaled bronchodilator therapy is currently the mainstay of treatment for patients with chronic obstructive pulmonary disease (COPD). Some inhalers require patients to achieve certain inhalation efforts either to activate the device or to deliver medication to the site of action. For dry powder inhalers, low peak inspiratory flow (PIF) can result in poor medication delivery but the clinical significance of this is not well understood.