Open AccessTranscriptomics Analysis Identifies the Presence of Upregulated Ribosomal Housekeeping Genes in the Alveolar Macrophages of Patients with Smoking-Induced Chronic Obstructive Pulmonary Disease
Author(s) -
Li Han,
Jing Wang,
Xiangyu Ji,
Zai-Yan Wang,
Yi Wang,
Liyue Zhang,
Hongpeng Liu,
Zeming Zhang,
Qingyun Li
Publication year - 2021
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s313252
Subject(s) - copd , transcriptome , medicine , gene , pulmonary disease , housekeeping gene , phenotype , ribosomal protein , gene expression , bioinformatics , pathology , biology , genetics , rna , ribosome
Alveolar macrophages (AM) play a crucial role in the development of chronic obstructive pulmonary disease (COPD). The role that AM plays in the molecular pathways and clinical phenotypes associated with tobacco-related emphysema remain poorly understood. Thus, we investigated the transcriptomic profile of AM in COPD patients with a history of smoking and explored the molecular mechanisms associated with enriched pathways and hub genes.