Open AccessCirc-RBMS1 Knockdown Alleviates CSE-Induced Apoptosis, Inflammation and Oxidative Stress via Up-Regulating FBXO11 Through miR-197-3p in 16HBE Cells
Author(s) -
Di Qiao,
Chi Hu,
Qiuyan Li,
Jun Fan
Publication year - 2021
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s311222
Subject(s) - gene knockdown , flow cytometry , apoptosis , western blot , oxidative stress , inflammation , microbiology and biotechnology , gene silencing , malondialdehyde , cancer research , chemistry , viability assay , tumor necrosis factor alpha , medicine , biology , immunology , biochemistry , gene
Emerging evidence has reported that circular RNAs (circRNAs) are aberrantly expressed and act as significant regulators in pathological processes of chronic obstructive pulmonary disease (COPD). Here, the purpose of this article was to evaluate and clarify the biological functions and mechanism of circRNA single stranded interacting protein 1 (circ-RBMS1) in cigarette smoke (CS)-induced COPD.