Open AccessExploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials
Author(s) -
Malcolm Begg,
J. Nicole Hamblin,
Emily Jarvis,
Glyn Bradley,
Stephen Mark,
David Michalovich,
Mark Len,
Hannah E Wajdner,
Augustin Amour,
Robert Wilson,
Ken Saunders,
Rikako Tanaka,
Saki Arai,
Teresa Tang,
Cedric Van Holsbeke,
Jan De Backer,
Wim Vos,
Ingrid Louise Titlestad,
J. Mark FitzGerald,
Kieran J. Killian,
Jean Bourbeau,
Claude Poirier,
François Maltais,
Anthony Cahn,
Edith M. Hessel
Publication year - 2021
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s309303
Subject(s) - medicine , copd , sputum , exacerbation , spirometry , clinical endpoint , placebo , randomized controlled trial , gastroenterology , immunology , pathology , asthma , tuberculosis , alternative medicine
Inhibition of phosphoinositide 3-kinase δ (PI3Kδ) exerts corrective effects on the dysregulated migration characteristics of neutrophils isolated from patients with chronic obstructive pulmonary disease (COPD).