Open AccessT-Helper 17 Cell/Regulatory T-Cell Imbalance in COPD Combined with T2DM Patients
Author(s) -
Cheng Wang,
Wang Hong,
Luming Dai,
Jianqing Zhang,
Lizhou Fang,
Ling Liu,
Weiping Fu,
Tang Dang
Publication year - 2021
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s306406
Subject(s) - copd , medicine , foxp3 , immunology , rar related orphan receptor gamma , inflammation , regulatory t cell , pathogenesis , flow cytometry , interleukin 17 , type 2 diabetes mellitus , t cell , diabetes mellitus , immune system , il 2 receptor , endocrinology
Chronic obstructive pulmonary disease (COPD) is often combined with type 2 diabetes mellitus (T2DM) in clinical, and with poor prognosis. In recent years, research shows that inflammation is a common characteristic of COPD and T2DM. T-helper 17 cell (Th17)/regulatory T-cell (Treg) balance controls inflammation and may be important in the pathogenesis of COPD combined with T2DM patients. This study investigated the characteristics of Th17, Treg and related inflammatory factors in COPD combined with T2DM patients and the potential mechanism.