Open AccessSputum Gene Expression Reveals Dysregulation of Mast Cells and Basophils in Eosinophilic COPD
Author(s) -
Natasha A Winter,
Péter G. Gibson,
Vanessa M. McDonald,
Michael Fricker
Publication year - 2021
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s305380
Subject(s) - copd , medicine , sputum , immunology , population , eosinophil , basophil , eosinophilia , asthma , pathology , immunoglobulin e , tuberculosis , antibody , environmental health
The clinical and inflammatory associations of mast cells (MCs) and basophils in chronic obstructive pulmonary disease (COPD) are poorly understood. We previously developed and validated a qPCR-based MC/basophil gene signature in asthma to measure these cells in sputum samples. Here, we measured this gene signature in a COPD and control population to explore the relationship of sputum MCs/basophils to inflammatory and COPD clinical characteristics.