Open AccessLongitudinal Relationship Between Growth Differentiation Factor 11 and Physical Activity in Chronic Obstructive Pulmonary Disease
Author(s) -
Rie Tanaka,
Akira Koarai,
Mitsuhiro Yamada,
Naoya Fujino,
Tomohiro Ichikawa,
Tadahisa Numakura,
Koichi Onodera,
Yorihiko Kyogoku,
Tsutomu Tamada,
Motohiko Miura,
Yoshiaki Minakata,
Masakazu Ichinose,
Hisatoshi Sugiura
Publication year - 2021
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s301690
Subject(s) - medicine , copd , exacerbation , biomarker , myokine , incidence (geometry) , physical activity , gdf15 , risk factor , prospective cohort study , systemic inflammation , gastroenterology , inflammation , cardiology , physical therapy , skeletal muscle , biochemistry , chemistry , physics , optics
Daily physical activity is reduced in patients with chronic obstructive pulmonary disease (COPD) and a reduced level of physical activity has been shown to be an important predictor for the prognosis, such as increased risk of exacerbation and mortality. However, there has not yet been a useful biomarker of the physical activity. In our previous cross-sectional study, we showed that the level of one of the possible myokines, which is an anti-aging factor, growth differentiation factor 11 (GDF11), was decreased in the plasma from patients with COPD and correlated with the physical activity. To clarify this relationship, we conducted a longitudinal evaluation of such factors.