Open Access<p>miRNA-486-5p Promotes COPD Progression by Targeting HAT1 to Regulate the TLR4-Triggered Inflammatory Response of Alveolar Macrophages</p>
Author(s) -
Jie Zhang,
Zhongneng Xu,
Lingyan Kong,
Hong Gao,
Yueming Zhang,
Yulong Zheng,
Yufeng Wan
Publication year - 2020
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s280614
Subject(s) - downregulation and upregulation , gene knockdown , tlr4 , microrna , medicine , microbiology and biotechnology , microarray analysis techniques , proinflammatory cytokine , tumor necrosis factor alpha , real time polymerase chain reaction , cancer research , inflammation , immunology , biology , gene expression , cell culture , gene , biochemistry , genetics
The aim of this study was to investigate the role of miRNA-486-5p in chronic obstructive pulmonary disease (COPD) progression and the underlying molecular mechanisms.