Open Access<p>Unreported and Overlooked: A Post Hoc Analysis of COPD Symptom-Related Attacks from the RISE Study</p>
Author(s) -
Gary T. Ferguson,
Tor Skärby,
Lars H. Nordenmark,
Rosa Lamarca,
Audrone Aksomaityte,
Dan Lythgoe,
Ileen Gilbert,
Frank Trudo
Publication year - 2020
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s277147
Subject(s) - formoterol , medicine , copd , exacerbation , post hoc analysis , bronchodilator , proportional hazards model , quality of life (healthcare) , incidence (geometry) , budesonide , asthma , physics , nursing , optics
Moderate and severe COPD exacerbations are a significant health-care burden, but patients also experience "mild" exacerbations, or COPD symptom-related attacks, which often go unreported. We aimed to define and then determine the incidence of COPD symptom-related attacks and their impact on future risk of moderate/severe exacerbations, health-related quality of life (HRQoL), and lung function. The effect of COPD maintenance therapy on the attack definition was then evaluated by comparing budesonide/formoterol with formoterol alone.