Open Access<p>LINC00987 Ameliorates COPD by Regulating LPS-Induced Cell Apoptosis, Oxidative Stress, Inflammation and Autophagy Through Let-7b-5p/SIRT1 Axis</p>
Author(s) -
Yuanyuan Wang,
Jingjing Chen,
Wei Wei Chen,
Ling Liu,
Mei Dong,
Juan Juan Ji,
Die Hu,
Nianzhi Zhang
Publication year - 2020
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s276429
Subject(s) - oxidative stress , apoptosis , autophagy , viability assay , western blot , gene knockdown , inflammation , downregulation and upregulation , microbiology and biotechnology , reactive oxygen species , medicine , immunology , biology , biochemistry , endocrinology , gene
Chronic obstructive pulmonary disease (COPD) is the third cause of disease-related death and brings a heavy burden to human health. Long non-coding RNA (lncRNA) was revealed to participate in COPD pathogenesis. This study aims to establish the effects and regulatory mechanism of lncRNA long intergenic non-coding 00987 (LINC00987) in lipopolysaccharide (LPS)-induced apoptosis, oxidative stress, inflammation and autophagy in BEAS-2B cells.