Open Access<p>PM2.5 Induces the Expression of Inflammatory Cytokines via the Wnt5a/Ror2 Pathway in Human Bronchial Epithelial Cells</p>
Author(s) -
Weifeng Zou,
Xiaoqian Wang,
Hong Wang,
Fang He,
Jinxing Hu,
Qing Sheng,
Zhu Tao,
Pixin Ran
Publication year - 2020
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s270762
Subject(s) - small interfering rna , medicine , transfection , interleukin 8 , signal transduction , wnt5a , secretion , downregulation and upregulation , interleukin , tumor necrosis factor alpha , inflammation , wnt3a , microbiology and biotechnology , cancer research , wnt signaling pathway , cytokine , biology , cell culture , biochemistry , gene , genetics
Recently, fine particulate matter (PM2.5) was identified as the main exposure risk for COPD, and inflammation is central to the development of COPD. In this study, we investigated whether PM2.5 can induce the secretion of interleukin-6 (IL-6), IL-8 and IL-1β in human bronchial epithelial cells (HBECs) in vitro via the wingless-related integration site 5A (Wnt5a)/receptor tyrosine kinase-like orphan receptor 2 (Ror2) signaling.