Open Access<p>Heterozygous Genotype rs17580 AT (PiS) in <em>SERPINA1</em> is Associated with COPD Secondary to Biomass-Burning and Tobacco Smoking: A Case–Control and Populational Study</p>
Author(s) -
Gloría Pérez-Rubio,
Enrique Ambrocio-Ortiz,
Luis Alberto López-Flores,
Ana Itzel Juárez-Martín,
Luis Octavio Jiménez-Valverde,
Susana Zoreque-Cabrera,
Gustavo Galicia-Negrete,
María Elena Ramírez-Díaz,
Filiberto Cruz-Vicente,
Manuel Castillejos-López,
Citlaltépetl Salinas-Lara,
Rafael de Jesús Hernández-Zenteno,
Alejandra RamírezVenegas,
Ramcés FalfánValencia
Publication year - 2020
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s247446
Subject(s) - copd , medicine , genotype , population , tobacco smoke , smoke , environmental health , genetics , biology , gene , physics , meteorology
The protease inhibitor S (PiS) and Z (PiZ) variants have been stated as the only genetic cause of chronic obstructive pulmonary disease (COPD) in Caucasians. However, its frequency in admixed populations is low. We aimed to identify genetic susceptibility between PiS (rs17580) and PiZ (rs28929474) polymorphisms with COPD related to tobacco smoking and biomass-burning smoke as well as to determine its frequencies in Mestizo and Amerindian populations from Mexico.