Open Access<p>Exploration of n-6 and n-3 Polyunsaturated Fatty Acids Metabolites Associated with Nutritional Levels in Patients with Severe Stable Chronic Obstructive Pulmonary Disease</p>
Author(s) -
Mingshan Xue,
Chuanxu Cai,
Lili Guan,
Yifan Xu,
Jinsheng Lin,
Yutian Zeng,
Haisheng Hu,
Rongchang Chen,
Hongman Wang,
Luqian Zhou,
Baoqing Sun
Publication year - 2020
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s245617
Subject(s) - medicine , copd , polyunsaturated fatty acid , linoleic acid , docosahexaenoic acid , arachidonic acid , pulmonary function testing , eicosapentaenoic acid , gastroenterology , body mass index , endocrinology , fatty acid , biochemistry , biology , enzyme
Severe chronic obstructive pulmonary disease (COPD) is the terminal stage of the disease characterized by declined lung function, malnutrition, and poor prognosis. Such patients cannot tolerate long-time sports rehabilitation owing to dyspnea and fail to achieve the desired therapeutic effect; therefore, increasing nutritional support will be an important strategy for them. The present study applied metabolomics technology to evaluate the correlation between serum concentrations of polyunsaturated fatty acid (PUFA) metabolites, nutritional status, and lung function in patients with COPD to provide a theoretical basis for accurate nutritional support.