Open Access<p>A Sputum 6 Gene Expression Signature Predicts Inflammatory Phenotypes and Future Exacerbations of COPD</p>
Author(s) -
Katherine J. Baines,
Netsanet A Negewo,
Péter G. Gibson,
Juanjuan Fu,
Jodie L. Simpson,
Peter Wark,
Michael Fricker,
Vanessa M. McDonald
Publication year - 2020
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s245519
Subject(s) - copd , medicine , exacerbation , neutrophilia , prospective cohort study , spirometry , area under the curve , sputum , gastroenterology , immunology , asthma , pathology , tuberculosis
The 6 gene expression signature (6GS) predicts inflammatory phenotype, exacerbation risk, and corticosteroid responsiveness in asthma. In COPD, patterns of airway inflammation are similar, suggesting the 6GS may be useful. This study determines the diagnostic and prognostic ability of 6GS in predicting inflammatory phenotypes and exacerbation risk in COPD.