Open Access<p>Serum Levels of Autoantibodies Against Extracellular Antigens and Neutrophil Granule Proteins Increase in Patients with COPD Compared to Non-COPD Smokers</p>
Author(s) -
Anqi Ma,
Lianggong Wen,
Youlun Ju,
Yi Hu,
Xiaoyang Yue,
Jiurong Li,
Xiaoru Dong,
Yask Gupta,
Ralf J. Ludwig,
Susanne KraussEtschmann,
Gabriela Riemekasten,
Frank Petersen,
Xinhua Yu
Publication year - 2020
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s235903
Subject(s) - copd , medicine , autoantibody , immunology , lactoferrin , autoimmunity , exacerbation , cohort , pathogenesis , antibody , biology , genetics
Chronic obstructive pulmonary disease (COPD) is a highly prevalent disease leading to irreversible airflow limitation and is characterized by chronic pulmonary inflammation, obstructive bronchiolitis and emphysema. Etiologically, COPD is mediated by toxic gases and particles, eg, cigarette smoke, while the pathogenesis of the disease is largely unknown. Several lines of evidence indicate a link between COPD and autoimmunity but comprehensive studies are lacking.