Open Access<p>Increased von Willebrand Factor Processing in COPD, Reflecting Lung Epithelium Damage, Is Associated with Emphysema, Exacerbations and Elevated Mortality Risk</p>
Author(s) -
Lasse Langholm,
Sarah Rank Rønnow,
Jannie Marie Bülow Sand,
Diana Julie Leeming,
Ruth TalSinger,
Bruce E. Miller,
Jørgen Vestbo,
Morten A. Karsdal,
Tina MaJensen
Publication year - 2020
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s235673
Subject(s) - medicine , von willebrand factor , copd , gastroenterology , pathophysiology , asymptomatic , immunology , platelet
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and lung tissue deterioration. Given the high vascularity of the lung, von Willebrand factor (VWF), a central component of wound healing initiation, has previously been assessed in COPD. VWF processing, which is crucial for regulating the primary response of wound healing, has not been assessed directly. Therefore, this study aimed to characterize wound healing initiation in COPD using dynamic VWF-processing biomarkers and to evaluate how these relate to disease severity and mortality.