Open Access<p>Sputum Vitamin D Binding Protein (VDBP) GC1S/1S Genotype Predicts Airway Obstruction: A Prospective Study in Smokers with COPD</p>
Author(s) -
Jing Gao,
Tanja Törölä,
Chuanxing Li,
Steffen Ohlmeier,
Tuula Toljamo,
Pentti Nieminen,
Noboru Hattori,
Ville Pulkkinen,
Hiroshi Iwamoto,
Witold Mazur
Publication year - 2020
Publication title -
international journal of chronic obstructive pulmonary disease/international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s234464
Subject(s) - vitamin d binding protein , copd , medicine , sputum , vitamin d and neurology , genotype , gastroenterology , immunology , pathology , biology , genetics , tuberculosis , gene
The vitamin D binding protein (VDBP, also known as GC-globulin) and vitamin D deficiency have been associated with chronic obstructive pulmonary disease (COPD). rs7041 and rs4588 are two single nucleotide polymorphisms of the VDBP gene, including three common allelic variants (GC1S, GC1F and GC2). Previous studies primarily assessed the serum levels of vitamin D and VDBP in COPD. However, less is known regarding the impact of the local release of VDBP on COPD lung function. Thus, we examined the association of sputum and plasma VDBP with lung function at baseline and at four years, and examined potential genetic polymorphism interactions.