Open AccessCMTM Family and Gastrointestinal Tract Cancers: A Comprehensive Review
Author(s) -
Jie Li,
Xiaozi Wang,
Xiaoning Wang,
Yan Liu,
Nanning Zheng,
Ping Xu,
Xianghong Zhang,
Liang Xue
Publication year - 2022
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s358963
Subject(s) - gastrointestinal tract , cancer , medicine , hepatocellular carcinoma , metastasis , gastrointestinal cancer , family member , chemokine , oncology , cancer research , immunology , bioinformatics , immune system , biology , colorectal cancer , family medicine
Gastrointestinal tract cancers are a highly heterogeneous group of malignant diseases, contributing significantly to the burden of death worldwide. Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTMs) plays important roles in cancer development and progression. Since the first member was cloned, there have been abundant studies on the relationships between the CMTM family and human cancers. It has been reported that the CMTM family has a large potential prognostic value for multiple cancers. Meanwhile, upregulated or downregulated expression of the family members was related to advanced tumor stage, metastasis, and overall survival. Studies have also reported that these proteins play critical roles in antitumor immunity. We performed a systematic review to sum up the latest advances of CMTM family' roles in gastrointestinal tract cancers, with a primary focus on hepatocellular carcinoma and gastric carcinoma.