Open AccessThe Radiation Dose to the Left Supraclavicular Fossa is Critical for Anastomotic Leak Following Esophagectomy – A Dosimetric Outcome Analysis
Author(s) -
Shang-Yu Chou,
Hung-I Lu,
YenHao Chen,
Chien-Ming Lo,
YunHsuan Lin,
TzuTing Huang,
FuMin Fang,
Lichun Chen,
Yu Chen,
YiChun Chiu,
YehPin Chou,
Shau-Hsuan Li,
Yuming Wang
Publication year - 2022
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s354667
Subject(s) - medicine , supraclavicular fossa , esophageal cancer , esophagectomy , radiation therapy , receiver operating characteristic , anastomosis , nuclear medicine , radiology , surgery , cancer , breast cancer
For locally advanced esophageal cancer, definitive concurrent chemoradiotherapy (CCRT) with a radiation dose of 50-50.4 Gy/25-28 Fx is prescribed, followed by adjuvant esophagectomy for better local control or salvage treatment if locoregional recurrence occurs. However, radiation injury before surgery may delay wound healing. We performed cervical anastomosis directly inside the left supraclavicular fossa (SCF), the irradiation target for esophageal cancer. The significance of radiation injury in patients with cervical anastomotic leak (AL) remains unclear. Thus, we assessed the influence of radiation on cervical AL in patients undergoing preoperative CCRT followed by esophagectomy.