Open AccessGrowth Inhibition of Retinoblastoma Cell Line by Exosome-Mediated Transfer of miR-142-3p
Author(s) -
Meropi Plousiou,
Alessandro De Vita,
Giacomo Miserocchi,
Erika Bandini,
Ivan Vannini,
Mattia Melloni,
Nestory Masalu,
Francesco Fabbri,
Patrizia Serra
Publication year - 2022
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s351979
Subject(s) - microvesicles , retinoblastoma , cell culture , cell growth , microbiology and biotechnology , cancer research , biology , tumor microenvironment , retinoblastoma protein , exosome , cell cycle , microrna , cell , chemistry , genetics , gene , tumor cells
Retinoblastoma (Rb) is the most common ocular paediatric malignancy and is caused by a mutation of the two alleles of the tumor suppressor gene, RB1 . The tumor microenvironment (TME) represents a complex system whose function is not yet well defined and where microvesicles, such as exosomes, play a key role in intercellular communication. Micro-RNAs (mRNAs) have emerged as important modifiers of biological mechanisms involved in cancer and been able to regulate tumor progression.