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Genetic alterations, including IDH, BRAF , and TERT promoter mutations ( IDH -mu, BRAF -mu, TERTp -mu, respectively), 1p/19q co-deletion (1p/19q-codel), and MGMT promoter methylation ( MGMTp -M), are correlated with glioma tumor development. Therefore, these genetic alterations could serve as biomarkers for the diagnosis, prognosis, and classification of gliomas, combined with the immunohistochemical markers Ki-67 and p53. However, the correlation between these alterations and the expression of Ki-67 and p53 is poorly understood.

cancer management and research

Clinical and Prognostic Implications of 1p/19q, IDH, BRAF, MGMT Promoter, and TERT Promoter Alterations, and Expression of Ki-67 and p53 in Human Gliomas