Open AccessDl-3-N-Butylphthalide Presents Anti-Cancer Activity in Lung Cancer by Targeting PD-1/PD-L1 Signaling
Author(s) -
Jiang Qian,
Nan Zhang,
Xin Li,
Wei Hou,
Xiaoqing Zhao,
Lei Liu
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s333416
Subject(s) - cancer , lung cancer , cancer research , pd l1 , medicine , signal transduction , pharmacology , oncology , chemistry , immunotherapy , biochemistry
Lung cancer serves as one of the most malignant cancer types. Immunotherapy targeting PD-1/PD-L1 axis is a promising strategy for cancer treatment. Dl-3-N-butylphthalide (NBP), a small molecule compound extracted from the seeds of Apium graveolens, possesses a large range of biological effects and demonstrates anti-cancer activities. However, the role of NBP in the modulation of lung cancer remains obscure.