Open AccessIntratumoral Injection of a Human Papillomavirus Therapeutic Vaccine-Induced Strong Anti-TC-1-Grafted Tumor Activity in Mice
Author(s) -
Yuxin Che,
Yang Yang,
Jinguo Suo,
Chang Chen,
Xuelian Wang
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s329471
Subject(s) - immune system , vaccination , cd8 , cancer research , chemokine , medicine , immunotherapy , adjuvant , cancer vaccine , cancer , immunohistochemistry , angiogenesis , immunology
The route of administration of a therapeutic tumor vaccine is a critical factor in inducing antitumor activity. In this study, we explored the effects of three vaccination routes (subcutaneous, peritumoral, and intratumoral injection) on antitumor activity induced by a human papillomavirus (HPV) therapeutic vaccine containing HPV16 E7 peptide combined with the adjuvant CpG ODN in established TC-1 grafted tumors.