Open AccessSilencing of LncRNA AFAP1-AS1 Inhibits Cell Proliferation in Oral Squamous Cancer by Suppressing CCNA2
Author(s) -
Tao Li,
Duanqin Liu,
Chenglong Li,
Lu Ru,
Xuixia Wang
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s328737
Subject(s) - cancer research , gene silencing , carcinogenesis , cell growth , metastasis , biology , downregulation and upregulation , cancer , oncology , medicine , gene , genetics
Evidence has indicated that dysregulation of long noncoding RNAs (lncRNA) is a critical factor in the occurrence of many diseases, including cancer. The lncRNA AFAP1-AS1 has been shown to participate in oncogenesis, metastasis, or drug resistance in many types of cancer. However, the potential role of AFAP1-AS1 in oral squamous cell carcinoma (OSCC) has not been fully elucidated.