Open AccessTargeted Inhibition of HK-II Reversed the Warburg Effect to Improve the Radiosensitivity of Laryngeal Carcinoma
Author(s) -
Xiaohong Chen,
Yu Du,
Jiang-Tao Zhong,
ShuiHong Zhou,
Jun Fan,
Lu Zhang
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s324754
Subject(s) - radiosensitivity , lactate dehydrogenase a , viability assay , pyruvate kinase , biology , glycolysis , lactate dehydrogenase , cell cycle , hexokinase , microbiology and biotechnology , cell growth , apoptosis , pyruvate dehydrogenase complex , warburg effect , cancer research , chemistry , biochemistry , medicine , metabolism , enzyme , radiation therapy
Hexokinase-II (HK-II) is the key enzyme in the first rate-limiting step of glycolysis that catalyzes the conversion of glucose to glucose-6-phosphate. Here, we examined the association between HK-II expression and radioresistance in laryngeal carcinoma and whether the inhibition of HK-II expression can enhance the radiosensitivity of these tumors.