Open AccessDifferent Clinicopathologic and Computed Tomography Imaging Characteristics of Primary and Acquired EGFR T790M Mutations in Patients with Non-Small-Cell Lung Cancer
Author(s) -
Donghui Hou,
Weihua Li,
Sicong Wang,
Yao Huang,
Jianwei Wang,
Wei Tang,
Lina Zhou,
Linlin Qi,
Ning Wu,
Suping Zhao
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s323972
Subject(s) - t790m , medicine , lung cancer , adenocarcinoma , epidermal growth factor receptor , oncology , mutation , ground glass opacity , pathology , osimertinib , radiology , cancer , gefitinib , gene , biology , genetics , ros1
Although patients with primary and acquired epidermal growth factor receptor (EGFR) T790M positive non-small-cell lung cancer (NSCLC) respond to osimertinib treatment, the optimal treatment strategy differs for these two groups of patients. This study aimed to compare the clinicopathologic and computed tomography (CT) imaging characteristics between primary and acquired EGFR T790M mutations in patients with NSCLC before treatment.