Open AccessIdentification and Functional Validation of Differentially Expressed microRNAs in Ascites-Derived Ovarian Cancer Cells Compared with Primary Tumour Tissue
Author(s) -
Yahui Jiang,
Yiwen Shi,
Tianjiao Lyu,
Hua Liu,
Lifei Shen,
Tianyu Zhou,
Weiwei Feng
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s320834
Subject(s) - ovarian cancer , microrna , ascites , metastasis , cancer research , biology , serous fluid , cancer , angiogenesis , gene , medicine , genetics , biochemistry
Ovarian cancer, manifested by malignant ascites, is the most lethal gynaecological cancer. Suspended ascites-derived spheroids may contribute to ovarian cancer metastasis. MicroRNAs (miRNAs) are also associated with ovarian cancer metastasis. Here, we aimed to investigate the differentially expressed miRNAs (DE-miRNAs) in ascites-derived spheroids compared with primary tumour tissues, which may regulate ovarian cancer metastasis.