Open AccessβKlotho Inhibits Cell Proliferation by Downregulating ELK4 and Predicts Favorable Prognosis in Prostate Cancer
Author(s) -
Changlin Mao,
Dong Wang,
Jiaju Lü,
Zhao Zhang,
Hongliang Wu,
Armin Ghavamian,
Dongbin Bi,
Pin Gao,
Zhao Liu,
Sentai Ding
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s320490
Subject(s) - klotho , prostate cancer , proportional hazards model , malignancy , medicine , p chloroamphetamine , cancer research , metastasis , survival analysis , oncology , cancer , receptor , kidney , serotonergic , serotonin
Prostate cancer (PCa) ranks as the second common malignancy in males worldwide. Although conspicuous progressions in diagnosis and treatment have been achieved in the past decades, the prognosis expectation of PCa remains unsatisfied yet. To improve the prognosis prediction of PCa, more specific biomarkers are needed. In this retrospective research, we focused on βKlotho and ETS-like transcription factor 4 (ELK4), aiming to identify potential prognostic biomarkers for PCa.