Open AccessIntrapulmonic Cavity or Necrosis on Baseline CT Scan Serves as an Efficacy Predictor of Anti-PD-(L)1 Inhibitor in Advanced Lung Squamous Cell Carcinoma
Author(s) -
Tong Lu,
Longfeng Zhang,
Mingqiu Chen,
Xiaobin Zheng,
Kan Jiang,
Xinlong Zheng,
Chao Li,
Weijin Xiao,
Miao Qin,
Shanshan Yang,
Gen Lin
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s319480
Subject(s) - necrosis , medicine , proportional hazards model , lung cancer , immunotherapy , lung , logistic regression , oncology , radiology , tumor necrosis factor alpha , gastroenterology , cancer
Predictive markers for guidance and monitoring of immunotherapy in lung squamous cell carcinoma (LSCC) are an interesting topic but have yet to be fully explored. A primary characteristic of LSCC is tumor necrosis that results in extensive immune suppression in patients. We sought to assess whether tumor necrosis or cavity on baseline CT could effectively predict the efficacy of immune checkpoint inhibitors (ICIs) in advanced LSCC.