Open AccessThe Role and Significance of Wnt5a in Regulating Epithelial–Mesenchymal Transition in Endometrioid Adenocarcinoma
Author(s) -
Ningning Yang,
Hongchun Chen,
YuChen Huang,
Xiaohong Song,
Panpan Yang,
Shan Zhang,
Wentian Yan,
Nan Li,
Zhenzhong Feng
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s319346
Subject(s) - cancer research , atypical hyperplasia , epithelial–mesenchymal transition , immunohistochemistry , wnt signaling pathway , adenocarcinoma , catenin , metastasis , biology , medicine , cancer , pathology , signal transduction , microbiology and biotechnology
As a non-classical ligand of Wnt, the abnormal regulation of Wnt5a contributes to the progression of malignant tumors; however, its effects differ depending on tumor type. Here, we evaluated the expression and significance of Wnt5a in endometrioid adenocarcinoma and its relationship with epithelial-mesenchymal transition (EMT)-related proteins.