Open AccessPatterns and Prevalence of BRCA1 and BRCA2 Germline Mutations Among Patients with Triple-Negative Breast Cancer: Regional Perspectives
Author(s) -
Hikmat AbdelRazeq,
Faris Tamimi,
Lama Abujamous,
Sara Edaily,
Mahmoud Abunasser,
Rayan Bater,
Osama Salama
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s316470
Subject(s) - medicine , breast cancer , family history , oncology , ovarian cancer , prophylactic mastectomy , cancer , genetic counseling , genetic testing , gynecology , germline mutation , triple negative breast cancer , mutation , mastectomy , gene , genetics , biology
Among all subtypes, patients with triple-negative (TN) breast cancer is known for their poor outcome and their higher risk of harboring BRCA1 or BRCA2 pathogenic mutations. Identification of such mutations has clinical impact on breast and ovarian cancer prevention and treatment decisions. We here report on patterns and prevalence of BRCA1 and BRCA2 mutations among Arab patients diagnosed with TN subtype.