Open AccessTargeting Notch4 in Cancer: Molecular Mechanisms and Therapeutic Perspectives
Author(s) -
Mengxi Xiu,
Xiaohong Zeng,
Renfeng Shan,
Wu Wen,
Jianfeng Li,
Ru Wan
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s315511
Subject(s) - notch signaling pathway , cancer research , epithelial–mesenchymal transition , cancer , cancer stem cell , signal transduction , angiogenesis , biology , mechanism (biology) , mesenchymal stem cell , microbiology and biotechnology , metastasis , genetics , philosophy , epistemology
The dysregulation of Notch signaling is found in many cancers and is closely related to cancer progression. As an important Notch receptor, abnormal Notch4 expression affects several tumor-cell behaviors, including stemness, the epithelial-mesenchymal transition, radio/chemoresistance and angiogenesis. In order to inhibit the oncogenic effects of Notch4 activation, several methods for targeting Notch4 signaling have been proposed. In this review, we summarize the known molecular mechanisms through which Notch4 affects cancer progression. Finally, we discuss potential Notch4-targeting therapeutic strategies as a reference for future research.