Open AccessAssociation of Tumour Microenvironment with Protein Glycooxidation, DNA Damage, and Nitrosative Stress in Colorectal Cancer
Author(s) -
Justyna Zińczuk,
Konrad Zaręba,
Joanna Kamińska,
Olga Martyna Koper-Lenkiewicz,
Violetta Dymicka-Piekarska,
Anna Pryczynicz,
Katarzyna GuzińskaUstymowicz,
Boguław Kędra,
Joanna Matowicka-Karna,
Małgorzata Żendzian-Piotrowska,
Anna Zalewska
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s314940
Subject(s) - peroxynitrite , nitrotyrosine , chemistry , oxidative stress , myeloperoxidase , colorectal cancer , glycation , biochemistry , antioxidant , cancer , nitric oxide synthase , medicine , inflammation , enzyme , receptor , superoxide
In this study, we evaluated the total antioxidant capacity, nitrosative stress, and protein/DNA oxidation and glycoxidation products in patients with colorectal cancer regarding histopathological parameters associated with the tumour microenvironment, such as inflammatory infiltration and tumour budding and compare all determined parameters between tumours located in the right and left side of the colon and normal mucosa.