Open AccessRole of Systemic Inflammatory Reaction in Female Genital Organ Malignancies – State of the Art
Author(s) -
Michał Mleko,
Kazimierz Pityński,
Elżbieta Pluta,
Aleksandra Czerw,
Katarzyna Sygit,
Beata Karakiewicz,
Tomasz Banaś
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s312828
Subject(s) - medicine , lymphocyte , systemic inflammation , c reactive protein , cancer , immunology , cervical cancer , breast cancer , oncology , inflammation
Systemic inflammatory reaction (SIR) is an unfavorable prognostic factor in many malignancies and has a role in all stages of the neoplastic process: initiation, promotion, and disease progression. Analysis of SIR can be performed by assessing indicators (eg, lymphocyte-to-neutrophil, platelet-to-lymphocyte, and monocyte-to-neutrophil ratios) and products of neutrophils and lymphocytes (ie, the systemic immune-inammation index), or by examining the relationship between levels of C-reactive protein and albumin (based on the Glasgow Prognostic Score, modified Glasgow Prognostic Score, and C-reactive protein-to-albumin ratio). Risk stratification is essential in the clinical management of cancer; hence, the evaluation of these factors has potential applications in the clinical management of patients with cancer and in the development of new therapeutic targets. This review summarizes the current knowledge on SIR indicators and presents their clinical utility in malignancies of the female genital organs.