Open AccessElevated mRNA Level of Y-Box Binding Protein 1 Indicates Unfavorable Prognosis Correlated with Macrophage Infiltration and T Cell Exhaustion in Luminal Breast Cancer
Author(s) -
Zhenhuan Lv,
Xue Cheng,
Lei Zhang,
Jian Sun,
Bin Cong
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s311650
Subject(s) - immune system , hazard ratio , medicine , foxp3 , t cell , breast cancer , cell , cancer research , oncology , gene knockdown , cancer , biology , immunology , confidence interval , cell culture , genetics
The Y-box binding protein 1 ( YBX1 ) gene encodes the multifunctional protein YB1 that is associated with the dysregulation of numerous cancer-related genes. However, the prognostic value of YBX1 and its correlation with immune cell infiltration in breast cancer (BRCA) remain unclear.