Open AccessSilencing UHRF1 Enhances Radiosensitivity of Esophageal Squamous Cell Carcinoma by Inhibiting the PI3K/Akt/mTOR Signaling Pathway
Author(s) -
Baojun Hui,
Shupei Pan,
Shaomin Che,
Yehuan Sun,
Yanli Yan,
Jia Guo,
Tuotuo Gong,
Juan Ren,
Xiaozhi Zhang
Publication year - 2021
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s311192
Subject(s) - pi3k/akt/mtor pathway , pten , protein kinase b , gene silencing , cancer research , radiosensitivity , apoptosis , biology , cell growth , downregulation and upregulation , chemistry , signal transduction , microbiology and biotechnology , medicine , biochemistry , radiation therapy , gene
Resistance to radiotherapy results in a high treatment failure rate for locally advanced esophageal squamous cell carcinoma (ESCC). Ubiquitin-like with plant homeodomain and ring-finger domains 1 (UHRF1), is associated with poor prognosis in ESCC. The present study aims to characterize the effect of UHRF1 silencing on the radiosensitivity of ESCC and its potential mechanism.